mu-opioid agonist
Medicina
Verbete 1 de 1
substantivo
Contexto: "The known cellular mechanisms of hyperalgesic priming are similar (PKC dependence and G-protein switch in cytokine hyperalgesia), whether the priming is induced by an inflammogen, a direct PKC activator, a Mu-opioid agonist, or stress. "
Fonte: Elizabeth K. Joseph, David B. Reichling, Jon D. Levine - Shared Mechanisms for Opioid Tolerance and a Transition to Chronic Pain Journal of Neuroscience 31 March 2010, 30 (13) 4660-4666; DOI: 10.1523/JNEUROSCI.5530-09.2010
Fonte: Elizabeth K. Joseph, David B. Reichling, Jon D. Levine - Shared Mechanisms for Opioid Tolerance and a Transition to Chronic Pain Journal of Neuroscience 31 March 2010, 30 (13) 4660-4666; DOI: 10.1523/JNEUROSCI.5530-09.2010
Termo equivalente: agonista (de receptor) mu-opioide
Definição: "Full mu-opioid agonists activate mu receptors, and increasing doses of full agonists produce increasing effects. Most opioids that are abused, such as morphine and heroin are full mu opioid agonists."
Fonte: Center for Substance Abuse Treatment. Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 2004. (Treatment Improvement Protocol (TIP) Series, No. 40.) 2 Pharmacology. Available from: https://www.ncbi.nlm.nih.gov/books/NBK64236/
Fonte: Center for Substance Abuse Treatment. Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 2004. (Treatment Improvement Protocol (TIP) Series, No. 40.) 2 Pharmacology. Available from: https://www.ncbi.nlm.nih.gov/books/NBK64236/
Definição em português: "Agonistas totais mu-opioide ativam receptores mu, e doses crescentes de agonistas completos produzem efeitos crescentes. A maioria dos opioides que são abusados, como a morfina e a heroína são opioides mu totais."